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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1428060Generated: October 30, 2026

HCID 59128565, compound → HCID 68439019, compound

https://huagongshe.com/reaction/1428060

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 59128565HCID 59128565—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductHCID 68439019HCID 6843901992.1%

Reaction Steps

A solution of 4-(1-methoxy-1,2,3,6-tetrahydro-pyridin-4-yl)-phenylamine (as prepared in previous step) (40.8 mg, 0.200 mmol) in MeOH (5 mL) was hydrogenated over 10% Pd/C (20.4 mg) at 20 psi for 1 h. The solution was filtered through a pad of Celite and concentrated to give 4-(1-methoxy-piperidin-4-yl)-phenylamine (38 mg, 92%) which was directly used in the next step without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08933091B2
Source datasetuspto-grants-2015_01
ORD IDord-48b5ce21cb01471080f1fe2b29ed42fc
Source noteuspto-grants-2015_01