Citric Acid → HCID 86700036, compound

Participants

Reaction Steps

Fifty-five percent sodium hydride (131 mg) dispersed in oil was added to a solution of 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (233 mg) in DMF (5 ml) under ice cooling, and the mixture was stirred at room temperature for one hour. Benzyl bromide (356 μl) was then added and the mixture was stirred for two days. A 1 N aqueous sodium hydroxide solution was then added, followed by stirring overnight. A 10% aqueous citric acid solution was added to the reaction solution, and the precipitate was collected by filtration to give the title compound (253 mg) as a solid.

Provenance & Evidence