Hydrochloric Acid → HCID 86700038, compound

Participants

Reaction Steps

2-(Bromomethyl)pyridine hydrobromide (126 mg) was added to a suspension of ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (100 mg) and cesium carbonate (437 mg) in DMF (2 ml) at room temperature. The reaction mixture was stirred at room temperature overnight. The reaction mixture was stirred at 80° C. for four hours and returned to room temperature. A 1 N aqueous sodium hydroxide solution (2 ml) was added to the reaction mixture at room temperature. The reaction mixture was stirred at room temperature for 1.5 hours. A 1 N aqueous hydrochloric acid solution and water were added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water and then dried to give 94 mg of the title compound as a solid.

Provenance & Evidence