Triethylamine → HCID 86700073, compound

Participants

Reaction Steps

3-Methoxyazetidine hydrochloride (67 mg), 1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (206 mg) and triethylamine (100 μl) were added to a solution of the compound obtained in Step 2 of Example 26 (110 mg) in dichloromethane/DMF (2.0/0.5 ml) at room temperature, and the mixture was stirred for seven hours. After adding a small amount of water, the mixture was diluted with ethyl acetate, followed by drying over sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography [chloroform:methanol=300:1->20:1 (v/v)] to give 63 mg of the title compound as an oily substance.

Provenance & Evidence