HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Aminopyridine-3-boronic acid, pinacol ester | HCID 43811067 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine | HCID 86700076 | 51.5% |
Reaction Steps
N-Bromosuccinimide (255 mg) was added to a solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (300 mg) in DMF (6.8 ml) at room temperature, and the mixture was stirred for four hours. Water was added and the precipitated solid was collected by filtration to give 210 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933103B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-4657539fb2ef4a72a457d2c930710a26 |
| Source note | uspto-grants-2015_01 |