HCID 86700082, compound → HCID 86700081, compound

HRID 1428133Notes

Reaction equation

HRID 1428133 reaction equation
O.[ClH:2].[NH2:3][C:4]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]3[C:24](=[O:25])[C:23]([C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=4)=[CH:22][N:21]([CH2:33][C:34]([F:37])([F:36])[F:35])[CH:20]=3)=[O:18])=[CH:12][CH:11]=2)=[CH:8][C:7]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[C:40]([O:46][CH3:47])[CH:39]=2)=[CH:6][N:5]=1>CC(C)=O>[ClH:2].[NH2:3][C:4]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]([C:19]3[C:24](=[O:25])[C:23]([C:26]4[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=4)=[CH:22][N:21]([CH2:33][C:34]([F:35])([F:36])[F:37])[CH:20]=3)=[O:18])=[CH:14][CH:15]=2)=[CH:8][C:7]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[C:40]([O:46][CH3:47])[CH:39]=2)=[CH:6][N:5]=1

Participants

3

Reactant 1

HCID 86700082HCID 86700082, compound

Product 1

HCID 86700081HCID 86700081, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
40 °C

Procedure

Acetone (200 μl) was added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide hydrochloride hydrate described in Example 92 (22.72 mg) at room temperature, and the mixture was stirred at 40° C. for about 24 hours. After leaving to stand at room temperature for about 30 minutes, the precipitated solid was collected by filtration. The solid was then dried at room temperature to give the title compound (21.11 mg). Yield: 89%.

Workup

  1. customAfter leaving
  2. waitto stand at room temperature for about 30 minutes
  3. filtrationthe precipitated solid was collected by filtration
  4. customThe solid was then dried at room temperature

Sources & evidence

ORD record
ord-2f5a02680b0343b5b5399048ad5c42cb
Source dataset
uspto-grants-2015_01
Patent number
US08933103B2

Reaction notes

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