HCID 46941731, compound → HCID 46941732, compound

Participants

Reaction Steps

A mixture of [4-(4-fluorophenyl)-2-(methylsulfanyl)pyrimidin-5-yl]methanol (10.3 g), Raney-nickel (77 g) and ethanol (500 mL) was heated under reflux for 2 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the title compound (4.8 g).

Provenance & Evidence