2-Chloropyridin-4-amine → HCID 58268946, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 10 ml 1,4-dioxane and 8 ml 4N KOAc (5.9 g) with 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine (13 g, 3.68 g) and 2-chloro-4-aminopyridine (3.68 g) was purged with nitrogen for 30 min. Then, to the suspension was added Pd(PPh3)4 (867 mg) and the reaction mixture was heated at 120° C. in microwave for 20 min. Upon cooling, the precipitated solid was filtered and used without further purification (1.0 g, 31% yield).

Provenance & Evidence