HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile → 2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile | HCID 66765678 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzylamine | HCID 66765816 | 99% |
Reaction Steps
2-fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile (2.85 g, 9.19 mmol) was hydrogenated in 40 mL saturated methanolic ammonia solution after the addition of 300 mg of Raney nickel at ambient temperature. After the catalyst had been filtered off and the mixture evaporated down the product was obtained in a yield of 99% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937073B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-d714d3e37a9547038799af71c6bf0b43 |
| Source note | uspto-grants-2015_01 |