5-Aminonicotinic Acid → butyl (S)-3-[(5-amino-pyridine-3-carbonyl)-amino]-tetrahydrofuran-3-carboxylate

HRID 1428207Notes

Reaction equation

HRID 1428207 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])=O)[CH:5]=[N:6][CH:7]=1.[NH2:11][C@@:12]1([C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:16][CH2:15][O:14][CH2:13]1>>[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C@@:12]2([C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:16][CH2:15][O:14][CH2:13]2)=[O:10])[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 3543165-Aminonicotinic AcidHCID 59621155Butyl (S)-3-aminotetrahydrofuran-3-carboxylate

Product 1

HCID 68025793butyl (S)-3-[(5-amino-pyridine-3-carbonyl)-amino]-tetrahydrofuran-3-carboxylateYield 96%

Procedure

Analogously to Example 1c), 5-aminopyridine-3-carboxylic acid (72.4 mmol) was reacted with n-butyl(S)-3-amino-tetrahydrofuran-3-carboxylate (72.4 mmol). The product was obtained in a yield of 96% of theory.

Workup

  1. customThe product was obtained in a yield of 96% of theory

Sources & evidence

ORD record
ord-2b0010348852452091a2a6b6559ab4fc
Source dataset
uspto-grants-2015_01
Patent number
US08937073B2

Reaction notes

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