HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-2-(trifluoromethyl)aniline → Tert-butyl[3-fluoro-5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-2-(trifluoromethyl)aniline | HCID 22601721 | — |
| Reactant | Tert-butyl ((5-bromo-3-fluoropyridin-2-YL)methyl)carbamate | HCID 68451985 | — |
| Product | Tert-butyl[3-fluoro-5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamate | HCID 68025880 | 26% |
Reaction Steps
Analogously to Example 1a), tert-butyl (5-bromo-3-fluoro-pyridin-2-ylmethyl)-carbamate (0.55 mmol) was reacted with 4-methoxy-2-trifluoromethyl-aniline. The crude product was purified by chromatography (column: Varian Pursuit XRS C18; 10 μM; 41.4×250 mm, gradient: acetonitrile/water/CF3COOH: 10/90/0.1→100/0/0.1). The product was thus obtained in a yield of 26% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937073B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-80b04ac597994e889fac3493aeb6144a |
| Source note | uspto-grants-2015_01 |