HRID1428212

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59496422

未命名化合物

结构：COc1ccc(Nc2cnc(CN)c(F)c2)c(C(F)(F)F)c1

HCID66765948

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Nc2cnc(CNC(=O)[C@]3(NC(=O)c4cncc(N)c4)CCOC3)c(F)c2)c(C(F)(F)F)c1

HCID56840396

未命名化合物

收率 34%

PROCEDURE

实验过程

Analogously to Example 1e), (S)-3-[(5-amino-pyridine-3-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid (from 2b) was reacted with (6-aminomethyl-5-fluoro-pyridin-3-yl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine. The product was obtained in a yield of 34% of theory.

WORKUP

后处理

customThe product was obtained in a yield of 34% of theory

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1986ad8b8f44128a41768dfd32df69a
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08937073B2
来源说明: uspto-grants-2015_01

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][C@@:11]2([C:16]([OH:18])=O)[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])[CH:5]=[N:6][CH:7]=1.[NH2:19][CH2:20][C:21]1[N:26]=[CH:25][C:24]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=2[C:36]([F:39])([F:38])[F:37])=[CH:23][C:22]=1[F:40]>>[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH:3]=1)[C:8]([NH:10][C@@:11]1([C:16](=[O:18])[NH:19][CH2:20][C:21]2[C:22]([F:40])=[CH:23][C:24]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=3[C:36]([F:39])([F:38])[F:37])=[CH:25][N:26]=2)[CH2:15][CH2:14][O:13][CH2:12]1)=[O:9]