HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 4-bromo- → 4-(4-Methoxy-2-trifluoromethyl-phenylamino)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 4-bromo- | HCID 12162 | — |
| Reactant | 4-Methoxy-2-(trifluoromethyl)aniline | HCID 22601721 | — |
| Product | 4-(4-Methoxy-2-trifluoromethyl-phenylamino)-benzonitrile | HCID 66765826 | 60.5% |
Reaction Steps
Analogously to Example 1a), 4-bromobenzonitrile was reacted with 2-trifluoromethyl-4-methoxy-aniline. After chromatographic purification through silica gel (petroleum ether with 10 to 30% ethyl acetate) the 4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile was obtained in a yield of 60.5% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937073B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-86b8c2da8ad44f178bbc2d1c101a0a8d |
| Source note | uspto-grants-2015_01 |