HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (4-Aminomethyl-phenyl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(4-Methoxy-2-trifluoromethyl-phenylamino)-benzonitrile | HCID 66765826 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-Aminomethyl-phenyl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine | HCID 66765571 | — |
Reaction Steps
3.7 g (12.7 mmol) of 4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile were hydrogenated in a 7N solution of ammonia in methanol (100 mL) with the addition of Raney nickel at ambient temperature. After the catalyst had been filtered off and the solvent distilled off, the crude product thus obtained was reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937073B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ba359a48b5cd4297b44ae174ad0da289 |
| Source note | uspto-grants-2015_01 |