HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyridine-2-carbonitrile → 5-(4-Methoxy-2-trifluoromethyl-phenylamino)-pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyridine-2-carbonitrile | HCID 817154 | — |
| Reactant | 4-Methoxy-2-(trifluoromethyl)aniline | HCID 22601721 | — |
| Product | 5-(4-Methoxy-2-trifluoromethyl-phenylamino)-pyridine-2-carbonitrile | HCID 68026023 | 97.4% |
Reaction Steps
Analogously to Example 1a) 5-bromo-pyridine-2-carbonitrile was reacted with 2-trifluoromethyl-4-methoxy-aniline. After chromatographic purification through silica gel (petroleum ether with 10 to 30% ethyl acetate) the 4-(4-methoxy-2-trifluoromethyl-phenyl-amino)-benzonitrile was obtained in a yield of 97.4% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937073B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-117192bdf9864ac1a7732ef940cb1d44 |
| Source note | uspto-grants-2015_01 |