反应详情

A solution of n-butyl(S)-3-[(5-tert-butoxycarbonylamino-pyridin-3-carbonyl)-amino]-tetra-hydrofuran-3-carboxylate (29.7 mmol) in 150 mL methanol was combined with 60 mL of 1N sodium hydroxide solution and stirred for three hours at ambient temperature. Then the methanol was distilled off, the solution was then washed with 50 mL tert-butylmethylether and then adjusted to pH 3 with 4N hydrochloric acid. The product that then precipitated was filtered off and further reacted without purification.

1. distillationThen the methanol was distilled off
2. washthe solution was then washed with 50 mL tert-butylmethylether
3. customThe product that then precipitated
4. filtrationwas filtered off
5. customfurther reacted without purification