HRID1428220

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1ccc(Nc2ccc(CN)nc2)c(C(F)(F)F)c1

HCID66616894

未命名化合物

反应SMILES：CC(C)(C)OC(=O)Nc1cncc(C(=O)N[C@@]2(C(=O)O)CCOC2)c1

HCID68026203

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(Nc2ccc(CNC(=O)[C@]3(NC(=O)c4cncc(NC(=O)OC(C)(C)C)c4)CCOC3)nc2)c(C(F)(F)F)c1

HCID68026201

未命名化合物

PROCEDURE

实验过程

Analogously to Example 1e), (S)-3-[(5-tert-butoxycarbonylamino-pyridine-3-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid (product from Example 5d, 1.7 mmol) was reacted with (6-aminomethyl-pyridin-3-yl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine (product from Example 5b, 1.7 mmol). The product was purified by chromatography (silica gel, dichloromethane with 0-10% methanol).

WORKUP

后处理

customThe product was purified by chromatography (silica gel, dichloromethane with 0-10% methanol)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-8e87c7731459408ebe9810b22aa005d8
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08937073B2
来源说明: uspto-grants-2015_01

反应SMILES

[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([C:15]([NH:17][C@@:18]2([C:23](O)=[O:24])[CH2:22][CH2:21][O:20][CH2:19]2)=[O:16])[CH:12]=[N:13][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:26][CH2:27][C:28]1[N:33]=[CH:32][C:31]([NH:34][C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][C:36]=2[C:43]([F:46])([F:45])[F:44])=[CH:30][CH:29]=1>>[CH3:42][O:41][C:38]1[CH:39]=[CH:40][C:35]([NH:34][C:31]2[CH:30]=[CH:29][C:28]([CH2:27][NH:26][C:23]([C@:18]3([NH:17][C:15]([C:11]4[CH:10]=[C:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH:14]=[N:13][CH:12]=4)=[O:16])[CH2:22][CH2:21][O:20][CH2:19]3)=[O:24])=[N:33][CH:32]=2)=[C:36]([C:43]([F:46])([F:44])[F:45])[CH:37]=1