HCID 77230727, compound → 1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, octahydro-7-methyl-, 1,1-dimethylethyl ester

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Reaction Steps

To the product of Step 1 (361 mg, 1.35 mmol) was added platinum(IV) oxide (310 mg, 1.37 mmol) in a Parr pressure flask. The flask was purged with nitrogen by successive evacuation/nitrogen backfills and then acetic acid (15 mL) was added. The reaction mixture was placed under hydrogen atmosphere by successive evacuation/hydrogen backfills and the reaction was shaken at 40 psi for 5 days. The reaction was then filtered through Celite and washed with AcOH and concentrated in vacuo to afford a crude oil that was taken onto the next step without further purification. LRMS calc'd for C13H25N2O2 [M+H]+, 241; found 241.

Provenance & Evidence