反应详情

温度

5 °C

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. The stirred mixture was added to a solution of fumaric acid (0.033 g, 0.28 mmol) in TFE (1 mL) at 40° C. Stirring of the resulting clear solution was continued for about 4 h at 40° C. and the solution was subsequently cooled to 5° C. and kept at this temperature overnight to obtain a precipitate. The precipitate was filtered to give Nilotinib fumarate form II.

1. customkept at this temperature overnight
2. customto obtain a precipitate
3. filtrationThe precipitate was filtered