Glutaric Acid → HCID 86688188, compound

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. to obtain a mixture. The mixture was stirred and added to a solution of glutaric acid (0.15 g, 1.14 mmol) in TFE (1 mL) at 40° C. The resulting clear solution was stirred for about 4 h at 40° C. and subsequently cooled to 5° C. and kept at this temperature overnight leading to precipitation. The precipitate was filtered and the filter cake was dried at 60° C. in a vacuum oven over 2 days to give Nilotinib glutarate form III.

Provenance & Evidence