Acetic Acid → HCID 86688195, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Nilotinib base (0.5 g, 0.94 mmol) in glacial acetic acid (2 mL, 4V) was stirred at 40° C. for 5 h. The clear yellow solution was then cooled to 5° C. and maintained at that temperature for 72 h. The mixture was then allowed to warm up to room temperature over a period of 1 h. A solid precipitate formed and was separated by filtration to give Nilotinib acetate form III.

Provenance & Evidence