Acetic Acid → HCID 86688195, compound

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (1.5 g, 2.83 mmol) in glacial acetic acid (5 mL, 3.3V) was heated to 40° C. leading to dissolution. A precipitate was observed after stirring the solution at 40° C. for about 10 min. The mixture was then sonicated at 40° C. for 1 h leading to a clear solution. The solution was then allowed to cool to room temperature while stirring. A precipitate formed and was filtered to give Nilotinib acetate form V as a white solid.

Provenance & Evidence