Acetic Acid → HCID 86688195, compound

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (3.00 g, 5.66 mmol) was suspended in glacial acetic acid (12 mL, 4V) and the resulting mixture was heated to 40° C. with stirring, leading to dissolution. Stirring was continued for another 5 h at the same temperature leading to gradual precipitation. The mixture was then cooled to −18° C. and maintained at this temperature over a period of 15 h, leading to the formation of a large solid block. The solid was allowed to warm to room temperature and then heated to 40° C. for 4 h leading to a viscous suspension. The suspension was filtered and the collected solid was dried in a vacuum oven (35 mmHg) at 40° C. for 24 h to give Nilotinib acetate form VI (1.57 g) as a yellow solid.

Provenance & Evidence