Formic Acid → HCID 86688197, compound

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. to obtain a mixture. The mixture was stirred and added to a solution of formic acid (0.052 g, 1.13 mmol) in TFE (1 mL) at 40° C. The resulting solution was stirred for about 4 h and subsequently cooled to 5° C. The mixture was kept at 5° C. overnight and then a 1 mL sample was taken from the mixture and evaporated to dryness under reduced pressure at 40° C. to give amorphous Nilotinib formate as characterized by the powder X-ray diffractogram depicted in FIG. 50.

Provenance & Evidence