Hydrogen Bromide → Nilotinib hydrobromide

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (0.5 g, 0.94 mmol) was dissolved in TFE (5 mL, 10V) to obtain a mixture. The mixture was stirred at 40° C. HBr (48% aq., 0.175 g, 1.1 eq) was added to the resulting clear pale yellow solution. The solution was stirred at 40° C. for 5 h. The mixture was then cooled to 5° C. while stirring for 16 h. The resulting precipitate was isolated by filtration to give Nilotinib hydrobromide form I.

Provenance & Evidence