Hydrogen Bromide → 1353151-22-0

Participants

Reaction Conditions

Reaction Steps

A mixture of Nilotinib base (2.00 g, 3.77 mmol) and TFE (12 mL, 6V) was stirred and heated to 55° C. to provide a clear pale yellow solution. The solution was cooled to 50° C. and HBr (48% aq, 0.4 mL, 8.31 mmol, 2.2 eq) was added. The resulting deep yellow solution was stirred at 50° C. for 1 h, and then cooled to ambient temperature. Stirring was continued for 2 h and then the mixture was cooled to 5° C. in an ice-bath. About ⅔V of the solvent were removed under reduced pressure and the resulting mixture was kept in a refrigerator (5° C.) overnight. A solid precipitated and was separated by filtration to give Nilotinib HBr form III.

Provenance & Evidence