Hydrogen Bromide → Nilotinib hydrobromide

Participants

Reaction Conditions

Reaction Steps

Nilotinib base Form A (4.00 g, 7.55 mmol) was suspended in EtOH abs. (40 mL, 10V) at room temperature. The suspension was heated to 80° C. and stirred for 30 min. HBr (48% aq., 0.9 mL, 7.78 mmol, 1.03 eq) was added in one portion. The suspension was stirred for one hour at 80° C. then cooled to ambient temperature by removal of the heating source. The stirring was then continued for about 20 h. A yellow solid was isolated by filtering the suspension thereby providing Nilotinib HBr form VIII. The sample was analyzed by PXRD (ARL X-ray powder diffractometer model X'TRA-019).

Provenance & Evidence