Hydrogen Bromide → Nilotinib hydrobromide

Participants

Reaction Conditions

Reaction Steps

Nilotinib base Form A (4.00 g, 7.55 mmol) was suspended in EtOH abs. (40 mL, 10V) at room temperature. The suspension was heated to 80° C. and stirred for 30 min. HBr (48% aq., 1.7 mL, 15.33 mmol, 2.03 eq) was added in one portion. The suspension was stirred for 1 h at 80° C. and then cooled to ambient temperature by removal of the heating source. Stirring was then continued for about 6 h. The resulting yellow solid was isolated by filtration to give Nilotinib HBr form IX. (ARL X-ray powder diffractometer model X'TRA-019).

Provenance & Evidence