Hydrogen Bromide → 1353151-22-0

Participants

Reaction Steps

Nilotinib base Form A (4.00 g, 7.55 mmol) was suspended in acetone (40 mL, 10V) at room temperature. The suspension was heated to reflux and stirred for 30 min. HBr (33% in acetic acid, 1.4 mL, 7.78 mmol, 1.03 eq) was added in one portion. The suspension was stirred for 1 h at reflux and then cooled to ambient temperature by removal of the heating source. The stirring was continued for about 6 h. The resulting yellow solid was isolated by filtration and dried in a vacuum oven (35 mmHg) at 70° C. for 15 h to give Nilotinib HBr form X as a yellow solid. (ARL X-ray powder diffractometer model X'TRA-019).

Provenance & Evidence