反应详情

The crude 1-bromo-4-isocyanato-2-(pentafluoro-λ6-sulfanyl)benzene obtained above was dissolved in DCM (70 mL). 4-(4-aminophenoxy)-N-methylpicolinamide (1.54 g, 6.34 mmol, 0.8 eq) was added at room temperature under N2. The mixture was stirred at room temperature for about 30 min, a lot of solid precipitated. DCM (30 mL) was added and made the mixture stirred at room temperature for 18 hrs. The solid was filtrated, washed with DCM (50 mL), dried under high vacuum to afford 2.6 g (yield 72%) of the title compound as a white solid.

1. customa lot of solid precipitated
2. additionDCM (30 mL) was added
3. stirringstirred at room temperature for 18 hrs
4. filtrationThe solid was filtrated
5. washwashed with DCM (50 mL)
6. customdried under high vacuum