Fluorobenzene → 1-(4-fluorophenyl)prop-2-en-1-one

HRID 1428426Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](Cl)(=[O:11])[CH:9]=[CH2:10].[Cl-].[Al+3].[Cl-].[Cl-]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH:9]=[CH2:10])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 10008Fluorobenzene

HCID 13140Acryloyl chloride

HCID 6451240Aluminum(III) Chloride

Product 1

HCID 111162231-(4-fluorophenyl)prop-2-en-1-one

Procedure

Fluorobenzene (0.5 mL), acryloyl chloride (0.23 g), and aluminium chloride (0.33 g) were treated in the same manner as described in Example 1 to obtain the title compound (90 mg).

Sources & evidence

ORD record: ord-d805860ce2da4125b8b8b444913bb677
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08937091B2

Reaction notes

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