Naphthalene → Thr1 inhibitor, 1

HRID 1428428Notes

Reaction equation

HRID 1428428 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[C:11](Cl)(=[O:14])[CH:12]=[CH2:13].[Cl-].[Al+3].[Cl-].[Cl-]>>[C:11]([C:7]1[CH:8]=[CH:9][C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH:6]=1)(=[O:14])[CH:12]=[CH2:13]

Participants

4

Reactant 3

HCID 931NaphthaleneHCID 13140Acryloyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 3799Thr1 inhibitor, 1Yield 41.2%

Procedure

Naphthalene (0.128 g), acryloyl chloride (0.11 g), and aluminium chloride (0.15 g) were treated in the same manner as described in Example 1 to obtain the title compound (75 mg).

Sources & evidence

ORD record
ord-f7dbd16b65974f3cbc2ada52426b80f5
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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