Benzene → 2-Chloroacetophenone

HRID 1428454Notes

Reaction equation

HRID 1428454 reaction equation
[CH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:7][CH2:8][C:9](Cl)=[O:10].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[Cl:7][CH2:8][C:9]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:10]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6577Chloroacetyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 107572-Chloroacetophenone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Benzene (0.5 mL), chloroacetyl chloride (120 mg), and aluminium chloride (180 mg) were reacted in dichloromethane (1.5 mL) at from −40° C. to room temperature for 2 hours. The resultant was treated in the same manner as described in Example 1 to obtain the title compound (11 mg).

Workup

  1. additionThe resultant was treated in the same manner

Sources & evidence

ORD record
ord-c101a31fa97b4cfa8b3eddaf8b29950f
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

Loading…