2-(2,3-Dihydro-1,4-benzodioxin-2-yl)ethanamine → 2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-ethylsulfamide

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Reaction Steps

The crude 2-(2,3 dihydrobenzo[1,4]dioxin-2-yl)ethylamine in dioxane (100 mL) was combined with sulfamide (3.0 g, 31 mmol) and heated to reflux for 2 h. The solution was cooled and evaporated in vacuo to yield an orange solid, which was purified by column chromatography (DCM:MeOH—10:1) to yield a white solid. The solid was re-crystallized from DCM to yield the title compound as a solid.

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