反应详情

To a stirred solution of (4-bromophenyl)methanamine (500 mg, 2.687 mmol) in pyridine were added methanesulfonyl chloride (0.4 mL, 5.106 mmol) at 0° C. The reaction mixture was stirred for 1 h, then diluted with dichloromethane. The mixture was washed with water. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. N-(4-bromobenzyl)methane-sulfonamide (675 mg) was obtained in 95% yield.

1. washThe mixture was washed with water
2. dry with materialThe organic layer was dried over magnesium sulfate
3. filtrationfiltered
4. customThe filtrate removed in vacuo
5. customThe crude was purified by column chromatography