Water → 2-(4-Cyano-3-methoxyphenyl)propanoic acid

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Reaction Steps

To a stirred solution of ethyl 2-(4-cyano-3-methoxyphenyl)propanoate (222 mg, 0.952 mmol) in co-solvent with tetrahydrofuran and water (1:1) were added sodium hydroxide (95 mg, 2.38 mmol). The reaction mixture was stirred for 15 h at room temperature, then acidified to pH 3-4 with acetic acid. The residue dissolved in ethyl acetate and washed with water and brine. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. 2-(4-Cyano-3-methoxyphenyl)propanoic acid (188 mg) was obtained as 96% yield.

Provenance & Evidence