Methanesulfonyl chloride → HCID 71539430, compound

Participants

Reaction Steps

To a stirred solution of 2-(4-(aminomethyl)-3-methoxyphenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide (151 mg, 0.33 mmol) in pyridine, cooled to 0° C., were added methanesulfonyl chloride (151 mg). The resulting reaction mixture was stirred for 15 h at room temperature. The mixture dissolved in dichloromethane and washed with 1N HCl. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. 2-(3-Methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide (example 78) (38 mg) was obtained as 22% yield.

Provenance & Evidence