反应详情

To a stirred solution of (2-methyl-4-nitrophenyl)methanamine (178 mg, 1.071 mmol) in pyridine, cooled to 0° C., were added methane sulfonylchloride (0.16 mL, 2.0349 mmol). The resulting reaction mixture was stirred for 2 h. The mixture dissolved in dichloromethane and washed with 1N HCl. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography to obtain N-(2-methyl-4-nitrobenzyl)methanesulfonamide (100 mg, 38%).

1. customThe resulting reaction mixture
2. washwashed with 1N HCl
3. dry with materialThe organic layer was dried over magnesium sulfate
4. filtrationfiltered
5. customThe filtrate removed in vacuo
6. customThe crude was purified by column chromatography