tert-Butanol → HCID 86679392, compound

Participants

Reaction Steps

Chlorosulfonyl isocyanate (0.063 mL) and t-butanol (0.07 mL) were mixed in dichloromethane. After 10 min a solution of (4-nitrophenyl)methanamine (100 mg, 0.657 mmol) in dichloromethane was added at 50° C. After stirring for 30 min the mixture was cooled to room temperature and triethylamine (0.11 mL) was added. The mixture was stirred for 3 h, extracted with ethyl acetate and washed with brine. Drying over magnesium sulfate, evaporation of the ethyl acetate and purification by column chromatography gave tert-butyl N-(4-nitrobenzyl)sulfamoylcarbamate (112 mg, 51%).

Provenance & Evidence