HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate → tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate | HCID 86679394 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate | HCID 86680228 | 102.9% |
Reaction Steps
10% Pd/C (42 mg) was added to a solution of tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate (135 mg) in ethanol and tetrahydrofuran. The mixture was charged with H2 and stirred for 6 h. The reaction mixture was filtered using celite and evaporated in vacuo to obtain tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate (127 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937092B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f2026a2f811d409e94ebb55f38fa5fbc |
| Source note | uspto-grants-2015_01 |