(2-m-Tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine → HCID 89455636, compound

Participants

Reaction Conditions

Reaction Steps

2-(N-(2-Fluoro-4-(phenoxycarbonylamino)benzyl)sulfamoylcarbamoyloxy)-2-methylpropan-1-ylium (100 mg, 0.225 mmol) was dissolved in acetonitrile. (2-m-Tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine (60 mg, 0.225 mmol) and 4-dimethylaminopyridine (27 mg) were added to the solution. The reaction mixture was stirred for overnight at 50° C. The mixture was extracted with ethyl acetate and washed with brine. Drying over magnesium sulfate, evaporation of the ethyl acetate and purification by column chromatography gave tert-butyl N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate (70 mg, 51%).

Provenance & Evidence