2-Nitrotoluene → HCID 10399255, compound

Participants

Reaction Steps

To a stirred solution of added potassium tertiary butoxide (2.05 g, 18.3 mmol) in dimethylformamide (10 mL) were slowly added the mixture of 1-methyl-2-nitrobenzene (1 g, 7.29 mmol) and ethyl-2-chloropropionate (0.98 mL, 7.70 mmol) at −30° C. The reaction mixture was stirred for 10 min and warmed to room temperature. The residue was dissolved with ethylacetate and neutralized with NaHCO3. The organic layer was washed with water two times, then dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. Ethyl 2-(3-methyl-4-nitrophenyl)propanoate (1.20 g) was obtained as 70% yield.

Provenance & Evidence