Methanesulfonyl chloride → HCID 71539337, compound

Participants

Reaction Steps

To a stirred solution of 2-(4-(aminomethyl)-3-methylphenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide (83 mg, 0.19 mmol) in pyridine was added methanesulfonyl chloride (0.02 mL, 0.24 mmol) The reaction mixture was stirred for overnight at room temperature. The mixture was diluted with ethylacetate and washed with 1N HCl and brine. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. 2-(3-Methyl-4-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide (example 97) (60 mg) was obtained as 61% yield.

Provenance & Evidence