Triethylamine → HCID 178473532, compound

Participants

Reaction Steps

A solution of 3,4-dimethoxyaniline (0.15 g, 1.0 mmol), ethyl isothiocyanatoformate (0.14 mL, 1.2 mmol) and DCM (10 mL) was stirred at room temperature for 1 h. Triethylamine (0.42 mL, 3.0 mmol), ethyl pyrazole-4-carboxylate (0.17 g, 1.2 mmol), and EDCl (0.19 g, 1.2 mmol) were added and the solution was stirred at room temperature for 5 h. The mixture was concentrated, diluted with water, and extracted with DCM. The organic layer was dried and concentrated to provide the crude titled compound (390 mg, 100%). This material was used without purification: MS (ESI): mass calcd. for C18H22N4O6, 390.4; m/z found, 391.4 [M+H]+.

Provenance & Evidence