Potassium Hydroxide → HCID 135860552, compound

Participants

Reaction Steps

A mixture of 1-(6,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester (0.28 g, 0.81 mmol), 1M aq. KOH (3.0 mL) and THF (3.0 mL) was stirred for 4 h. The mixture was concentrated to remove the THF and the aqueous residue was acidified to pH 2 with 1M aq. HCl. The resulting precipitate was collected by filtration to provide the titled compound (0.23 g, 89%). MS (ESI): mass calcd. for C14H12N4O5, 316.3; m/z found, 317.1 [M+H]+. 1H NMR (400 MHz, DMSO-d6): 13.32-12.29 (br m, 2H), 8.90 (s, 1H), 8.22 (s, 1H), 7.47 (s, 1H), 7.19 (s, 1H), 3.93 (s, 3H), 3.89 (s, 3H).

Provenance & Evidence