(3-Phenylphenyl)boronic acid → HCID 135895254, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (product from Example 69, step B) and biphenyl-3-boronic acid. MS (ESI): mass calcd. for C24H16N4O3, 408.1; m/z found, 409.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (s, 1H), 12.92 (s, 1H), 9.00 (s, 1H), 8.44 (s, 1H), 8.32-8.25 (m, 2H), 8.01 (s, 1H), 7.83-7.77 (m, 4H), 7.72 (d, J=7.8 Hz, 1H), 7.62 (t, J=7.7 Hz, 1H), 7.53-7.48 (m, 2H), 7.43-7.40 (m, 1H).

Provenance & Evidence