Hydrochloric Acid → HCID 135895266, compound

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Reaction Steps

A mixture of 1-(7-benzenesulfonyl-4-oxo-3,4-dihydro-quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid, ethyl ester (50 mg, 0.12 mmol), THF (2 mL) and aqueous 1M LiOH (0.6 mL, 0.6 mmol) was stirred for 16 h. The THF was removed under reduced pressure and aqueous 1M HCl (3 mL, 3 mmol) was added. The crude product was collected by filtration and purified by HPLC to afford the titled compound (7.0 mg, 14%). MS (ESI): mass calcd. for C18H12N4O5S, 396.1; m/z found, 397.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.43-12.81 (m, 2H), 8.99 (s, 1H), 8.34-8.25 (m, 2H), 8.18 (s, 1H), 8.05 (d, J=7.6, 2H), 7.96 (dd, J=8.3, 1.5, 1H), 7.78-7.71 (m, 1H), 7.71-7.63 (m, 2H).

Provenance & Evidence