1H-Indol-6-ylboronic acid → HCID 136027570, compound

Participants

Reaction Steps

The titled compound was prepared in a manner analogous to Example 69, steps C-E, using 1-[6-iodo-4-oxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (Example 69 product from step B) and indole-6-boronic acid in step C. MS (ESI): mass calcd. for C20H13N5O3, 371.1; m/z found, 372.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6): 13.01 (s, 1H), 12.86 (s, 1H), 11.23 (s, 1H), 8.99 (s, 1H), 8.37 (s, 1H), 8.27 (s, 1H), 8.20 (s, 1H), 7.77 (s, 2H), 7.67 (d, J=8.2 Hz, 1H), 7.43 (s, 2H), 6.48 (s, 1H).

Provenance & Evidence