Potassium Hydroxide → HCID 136027634, compound

Participants

Reaction Steps

Aqueous potassium hydroxide (1M, 2.6 mL, 2.6 mmol) was added to 1-(8-oxo-2,3,7,8-tetrahydro-1,4-dioxa-5,7-diaza-phenanthren-6-yl)-1H-pyrazole-4-carboxylic acid ethyl ester (0.298, 0.869 mmol) in THF (2.6 mL). The reaction mixture was allowed to stir at room temperature for 2 days and was then concentrated. The residue was redissolved in water (10 mL) and brought to pH 1 with 1M aqueous HCl. The resulting precipitate was collected by filtration to yield the titled compound (0.235 g, 85% yield). MS (ESI/Cl): mass calcd. for C14H10N4O5, 314.1; m/z found, 315.1 [M+H]+. 1H NMR (400 MHz, DMSO-d6): 13.01 (s, 1H), 12.73 (s, 1H), 8.86 (d, J=0.7 Hz, 1H), 8.24 (d, J=0.6 Hz, 1H), 7.61 (d, J=8.8 Hz, 1H), 7.05 (d, J=8.7 Hz, 1H), 4.40 (s, 4H).

Provenance & Evidence