Indan-5-amine → HCID 136337178, compound

HRID 1428853Notes

Reaction equation

HRID 1428853 reaction equation
C1C2C(=CC(N)=CC=2)CC1.[CH2:11]([O:13][C:14]([C:16]1[CH:17]=[N:18][N:19]([C:21]2[NH:30][C:29](=[O:31])[C:28]3[C:27]4[CH2:32][CH2:33][CH2:34][C:26]=4[CH:25]=[CH:24][C:23]=3[N:22]=2)[CH:20]=1)=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1[CH:17]=[N:18][N:19]([C:21]2[NH:30][C:29](=[O:31])[C:28]3[C:23](=[CH:24][C:25]4[CH2:32][CH2:33][CH2:34][C:26]=4[CH:27]=3)[N:22]=2)[CH:20]=1)=[O:15])[CH3:12]

Participants

3

Reactant 2

HCID 90496Indan-5-amineHCID 136337179HCID 136337179, compound

Product 1

HCID 136337178HCID 136337178, compound

Procedure

The titled compound was prepared in a manner analogous to Example 131, steps A-B, using indan-5-ylamine in step A. Step B yielded a 10:1 mixture of the titled compound and 1-(1-oxo-2,7,8,9-tetrahydro-1H-cyclopenta[f]quinazolin-3-yl)-1H-pyrazole-4-carboxylic acid ethyl ester.

Workup

  1. customThe titled compound was prepared in a manner analogous to Example 131, steps A-B
  2. customStep B yielded

Sources & evidence

ORD record
ord-bea0d73b47a947b294bec0980bd72683
Source dataset
uspto-grants-2015_01
Patent number
US08937078B2

Reaction notes

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